LrgpV1, Main, Exploration, bibRecord, 002500

Synthesis and structure of AzAsx-Pro-containing Aza-peptides

Identifieur interne : 002500 ( Main/Exploration ); précédent : 002499; suivant : 002501

Synthesis and structure of AzAsx-Pro-containing Aza-peptides

Auteurs : Frédéric André [France] ; Michel Marraud (chimiste) [France] ; Guy Boussard [France] ; Claude Didierjean [France] ; André Aubry (chimiste) [France]

Source :

Tetrahedron Letters [ 0040-4039 ] ; 1995.

RBID : ISTEX:6F33326EE98EC3ED18CDB5FED0348D4A132A00FB

English descriptors

KwdEn :
- Amide, Amide bond, Amino, Amino acids, Azxaa, Carbonylating agent, Crystal structures, Intramolecular hydrogen bond, Marcel dekker, Peptide, Peptide analogues, Proline, Proline nitrogen, Side chain, Standard distance.
Teeft :
- Amide, Amide bond, Amino, Amino acids, Azxaa, Carbonylating agent, Crystal structures, Intramolecular hydrogen bond, Marcel dekker, Peptide, Peptide analogues, Proline, Proline nitrogen, Side chain, Standard distance.

Abstract

Abstract: One possible α-modification in peptides is the substitution of a nitrogen for the CαH group. We propose triphosgene as a carbonylating agent for coupling the properly substituted hydrazide to the proline nitrogen to obtain the AzAsx-Pro or AzAla-Pro aza-sequence (Az denotes the N CαH replacement, and Asx stands for Asn or Asp). The structure of three Z-AzAsx-Pro-NHiPr and of the Boc-AzAla-Pro-NHiPr aza dipeptides has been studied in solution by 1H-NMR and IR spectroscopy, and three of them have been investigated in the crystalline state by X-ray diffraction.

Url:

https://api.istex.fr/document/6F33326EE98EC3ED18CDB5FED0348D4A132A00FB/fulltext/pdf

DOI: 10.1016/0040-4039(95)02124-8

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Istex, to step Curation: 000670
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to stream Main, to step Merge: 002A20
to stream Main, to step Curation: 002500

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: One possible α-modification in peptides is the substitution of a nitrogen for the CαH group. We propose triphosgene as a carbonylating agent for coupling the properly substituted hydrazide to the proline nitrogen to obtain the AzAsx-Pro or AzAla-Pro aza-sequence (Az denotes the N CαH replacement, and Asx stands for Asn or Asp). The structure of three Z-AzAsx-Pro-NHiPr and of the Boc-AzAla-Pro-NHiPr aza dipeptides has been studied in solution by 1H-NMR and IR spectroscopy, and three of them have been investigated in the crystalline state by X-ray diffraction.</div>
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Synthesis and structure of AzAsx-Pro-containing Aza-peptides

Synthesis and structure of AzAsx-Pro-containing Aza-peptides

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri